易忠胜，教授，理学博士，博士研究生导师
1970年6月出生。主要从事分析化学、理论环境化学和计算环境毒理学方面的教学与研究工作，中国毒理学会计算毒理专业委员会委员，中国化学会会员，中国毒理学会会员，担任广西/江西/河北/海南省科技项目评审专家，Chemical Engineering Journal，Environment International，Chemosphere，Food Chemistry，Journal of the Science of Food and Agriculture等学术期刊的评审专家。先后主持国家自然科学基金项目4项，广西自然科学4项，863计划子项目1项，国家重点实验开放基金1项。在International Journal of Biological Macromolecules，Chemosphere，Analytical and Bioanalytical Chemistry等权威学术期刊发表SCI论文40余篇。
近期发表的代表论著:
1. Wangli Miao, Dan Jia, Jie Xu, Li Yong, Zhongsheng Yi*. Probing the binding interactions between perfluoroalkyl carboxylic acids and adenosine A2A receptors by spectroscopic techniques, molecular simulations and quantum chemistry. Journal of Molecular Liquids. 2023, 377: 121565. (https://doi.org/10.1016/j.molliq.2023.121565， https://authors.elsevier.com/a/1giH-c8qpaSmf)
2. Wangli Miao, Dan Jia, Yuefan Rui, Wenhui Liang, Yanting Chen, Hongyan Liu, Zhongsheng Yi*. Interaction Mechanisms of the Binding of Polychlorinated Biphenyls to Thyroid Hormone Transporters Revealed based on Quantum Chemistry and Spectroscopy. Journal of Molecular Structure. 2023, 1281: 135104. (https://doi.org/10.1016/j.molstruc.2023.135104, https://authors.elsevier.com/a/1gZgU54JUV0U6)
3. Dan Jia, Wangli Miao, Yuefan, Rui, Yanting Chen, Wenhui Liang, ZhongshengYi*. Thyroid hormone transporters binding affinity of methoxypoly chlorinated biphenyls: Insights from molecular simulations and fluorescence competitive binding experiment. International Journal of Biological Macromolecules. 2023, 231: 123224 (https://doi.org/10.1016/j.ijbiomac.2023.123224)
4. Dan Jia, Wangli Miao, Muwei Huang, Xiaomei Huang, Zhongsheng Yi*. Investigations on the binding properties of hydroxylated polybrominated diphenyl ethers with lysozyme using the multispectral techniques and molecular modeling. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2023: 121864. (https://doi.org/10.1016/j.saa.2022.121864).
5. Muwei Huang, Xiaomei Huang, Li Yong, Dan Ja, Wangli Miao, Hongyan Liu*, Zhongsheng Yi*. Insight on the microscopic binding mechanism of bisphenol compounds (BPs) with transthyretin (TTR) based on multi-spectroscopic methods and computational simulations. Analytical and Bioanalytical Chemistry (Paper in Forefront). 2022. 414(13): 3765-3780. (https://doi.org/10.1007/s00216-022-04028-0, https://rdcu.be/cKYoz; https://rdcu.be/cLmTQ)
6. Xiaomei Huang, Muwei Huang, Li Yong, Dan Jia, Wangli Miao, Zhongsheng Yi*, Hongyan Liu*. Study on Spectral Method and Computational Simulation of Chlorinated Bisphenol Compound and Thyroxine-Binding Globulin. ChemistrySelect. 2022, 7(11): e202104376 (https://doi.org/10.1002/slct.202104376) (https://onlinelibrary.wiley.com/share/author/QZKAFUIZYS87FSQFA9FI?target=10.1002/slct.202104376)
7. Wei Yuchen, Xu Jie, Huang Muwei, Rui Yuefan, Wu Zhiwei, Yi Zhongshengsheng*. Photophysical properties and dynamics simulation of the interaction between human serum albumin and hydroxy polybrominated diphenyl ether[J]. Spectroscopy Letters, 2022, 55(2): 114-127. (https://doi.org/10.1080/00387010.2022.2029492)
8. Muwei Huang, Xiaomei Huang, Yanqiu Zuo, Zhongsheng Yi*, Hongyan Liu*. Exploring the toxic effects and mechanism of methoxylated polybrominated diphenyl ethers (MeO-PBDEs) on thyroxine-binding globulin (TBG): Synergy between spectroscopic and computations. Luminescence, 2021, 36(7): 1621-1631. (http://doi.org/10.1002/bio.4103)
9. Manting Huang, Li Yong, Jie Xu, Yanqiu Zuo, Zhongsheng Yi*, Hongyan Liu*. Determinants of Adenosine A2A Receptors‐Perfluoroalkyl Sulfonates Complex: Multi‐Spectroscopic and Molecular Dynamics Simulation Study[J]. Chemistryselect. 2021, 6(19): 4633-4644. (http://dx.doi.org/10.1002/slct.202100863). (https://onlinelibrary.wiley.com/share/author/IBZMMV5JR3NK2B48T7NM?target=10.1002/slct.202100863)
10. Xiaomei Huang, Muwei Huang, Yanqiu Zuo, Zhongsheng Yi*, Hongyan Liu*. Binding characteristics of hydroxylated polybrominated diphenyl ether with thyroid protein and its potential toxicity[J]. Journal of Molecular Structure. 2021, 1236:130285. (https://doi.org/10.1016/j.molstruc.2021.130285)
11. Rui Yuefan, Zuo Yanqiu, Yang Lulu, Xu Jie, Wei Yuchen, Zhongsheng Yi*, Molecular dynamics and spectral analysis for the binding of methoxylated polybrominated diphenyl ethers to lysozyme[J]. Journal of Molecular Structure. 2020, 1226: 129329 (https://doi.org/10.1016/j.molstruc.2020.129329)
12. Yong Li, Huang Manting, Wei Yuchen., Xu Jie, Yi Zhongsheng*. Investigating the interaction between three perfluorinated carboxylic acids and the G protein-coupled estrogen receptor: spectroscopic analyses and computational simulations[J]. Analytical Methods, 2020, 12(31): 3944-3953. (https://doi.org/10.1039/D0AY01052A)
13. Zuo Yanqiu, Yi Zhongsheng*, Xu Jie, Rui Yuefan, Wei Yuchen, Liu Hongyan. Molecular simulation and spectroscopic studies on the interaction between perfluorohexadecanoic acid and human serum albumin[J]. Indian J. Biochem. Biophys., 2019, 56(3): 185-192.
14. Zuo Yanqiu, Rui Yuefan, Xu Jie, Yang Llu, Yi Zhongsheng.* Multi-spectroscopic and molecular dynamics simulations investigation of the binding mechanism of polybrominated diphenyl ethers to hen egg white lysozyme[J]. Luminescence, 2019, 34(7): 749-758. (https://doi.org/10.1002/bio.3669)
15. Yang Lulu, Yang Wu, Yi Zhongsheng, Zhao Sai, Duan Jiaxi. Study on the Interaction of Tetra-Brominated Diphenyl Ethers (BDE47) with Lysozyme[J]. Spectrosc. Spectr. Anal., 2019, 39(11): 3614-3618. (http://www.gpxygpfx.com/article/2019/1000-0593-39-11-3614.html)
16. Li Jiao., Xu Jie, Jin Wenying, Yi Zhongsheng*, Cai Chenbo, Huang Xuefen, Nie Jjinfang, Zhang Yun. Fluorescent kinetics combined with fourth-order calibration for the determination of diclofenac sodium in environmental water[J]. Analytical and Bioanalytical Chemistry, 2019, 411(10): 2019-2029. (https://doi.org/10.1007/s00216-019-01624-5)
17. Liu Hongyan*, Zhang Zexiong, Xie Shiwei, Xin He, Zhu Yinian, Li Haiyun, Yi Zhongsheng*. Study on transformation and degradation of bisphenol A by Trametes versicolor laccase and simulation of molecular docking[J]. Chemosphere, 2019, 224: 743-750. (https://doi.org/10.1016/j.chemosphere.2019.02.143)
18. XuJie, WeiYuchen, Yang Wu, Yang Lulu, Yi Zhongsheng*.*The Mechanism and Conformational Changes of Polybrominated Diphenyl Ethers to TTR By Fluorescence Spectroscopy, Computer Simulation, and Quantum Chemical. Analyst. 2018, 143(19): 4662-4673. (https://doi.org/10.1039/C8AN00435H)
19. 徐婕，魏雨晨，伍智蔚，易忠胜*. 基于酸度诱导的HSA与BDE154的光谱和计算模拟研究. 化学学报. 2018, 76(5): 408-414. (https://doi.org/10.6023/A18020060)
20. Wei Yuchen, Yi Zhongsheng*, Xu Jie, Yang Wu, Yang Lulu, Hongyan Liu*. Study on the binding characteristics of hydroxylated polybrominated diphenyl ethers and thyroid transporters using the multispectral technique and computational simulation. J. Biomol. Struct. Dyn., 2019, 37(6): 1402-1413. (https://doi.org/10.1080/07391102.2018.1461134)
21. Xu Jie., Yi Zhongsheng*, Wei Yuchen, Yang Wu, Yang Lulu, Nie Jinfang. Probing the Binding Mechanism of Polybrominated Diphenyl Ethers with Transthretin by Multi-Spectroscopic and Molecular Dynamics Simulations (J). Analytical Methods, 2017, 9(26): 3929-3940. (https://doi.org/10.1039/C7AY00838D)
22. Yang Wu, Yang Lulu, Yi Zhongsheng*, Wu Zhiwei, Nie Jinfang, Zhang Aiqian. Investigating the affinity of BDE154 and 3OH-BDE154 with HSA: Experimental and simulation validation (J). Environmental Toxicology and Pharmacology, 2017, 51: 85-93. (https://doi.org/10.1016/j.etap.2017.03.004)
23. Yang Lulu, Yang Wu, Wu Zhiwei, Yi Zhongsheng*. Binding of hydroxylated polybrominated diphenyl ethers with human serum albumin: Spectroscopic characterization and molecular modeling (J). Luminescence, 2017, 32(6): 978–987. (https://doi.org/10.1002/bio.3280)
24. 杨露露, 杨雾, 伍智蔚, 易忠胜*. 计算模拟与光谱法研究 4-羟基-2, 2’, 3, 4’-四溴二苯醚与人血清白蛋白的相互作用(J). 化学通报, 2017, 80(2), 185-190.
25. 董露, 易忠胜*, 伍智蔚, 王海洋, 张爱茜. 结合光谱法和计算模拟多角度分析2,2',4,4',5⁃五溴二苯醚与人血清白蛋白的作用机制(J). 环境科学学报, 2016, 36(1), 332-339. (https://www.actasc.cn/hjkxxb/ch/reader/create_pdf.aspx?file_no=20150315001&year_id=2016&quarter_id=1&falg=1)
26. 伍智蔚, 易忠胜*, 董露, 杨露露, 杨雾, 张爱茜. 模拟和光谱相互验证2'-OH-BDE-28对HSA构象的影响(J). 生态毒理学报, 2016, 11(1), 159-166. (http://www.stdlxb.cn/article/doi/10.7524/AJE.1673-5897.20150513001?viewType=HTML)
27. Wu Zhiwei, Yi Zhongsheng*, Dong Lu, Zhang Aiqian. Molecular simulation study of the specific combination between four kinds of phthalic acid esters and human serum albumin (J). Environmental Toxicology and Pharmacology, 2016, 41: 259-265. (https://doi.org/10.1016/j.etap.2015.12.017)
28. 董露, 易忠胜*, 伍智蔚, 王海洋, 张爱茜. 2'-羟基-2, 4-二溴二苯醚与人血清白蛋白作用机制的光谱研究与计算模拟(J). 高等学校化学学报, 2015, 36(3), 516-522. (http://www.cjcu.jlu.edu.cn/CN/10.7503/cjcu20141007)
29. 蒙延娟, 易忠胜*, 艾芳婷, 张爱茜. 基于对接的植物激素3D-QSAR和分子动力学模拟(J). 环境化学, 2014, 33(6), 880-890.
30. Yi Zhongsheng*, Zhang Aiqian. A QSAR Study of Environmental Estrogens Based on a Novel Variable Selection Method (J). Molecules, 2012, 17(5), 6126-6145. (https://doi.org/10.3390/molecules17056126)
31. Nie Jinfang*, Zhang Yun, Yi Zhongsheng, Zou Hongyan, Fu Haiyan, Wu Hailong. Advanced chemometric algorithm coupled to subspace projection technique between original and pseudo samples: A snapshot of chemical rank estimation for high-order data (J). Chemometr. Intell. Lab. Syst., 2012, 118(1), 211-218. (https://doi.org/10.1016/j.chemolab.2012.06.003)
32. Yi Zhongsheng*, Li Lianchen, Zhang Aiqian, Wang L. New Modes for the Prediction of Gas Chromatographic Relative Retention Times of Polybrominated Diphenyl Ethers (J). Chin. J. Chem, 2011, 29(11), 2495-2504. (https://doi.org/10.1002/cjoc.201100039)
近年主持和参与的项目：
1. 2022.04-2025.03，有机磷酸酯与G蛋白偶联雌激素受体结合机制研究，广西科技计划项目，2022GXNSFAA035448，主持，广西科技厅
2. 2022.01-2025.12，酚、酯类污染物与G蛋白偶联雌激素受体结合机制及结构依赖性研究，国家自然科学基金，22166015，主持，国家基金委
3. 2019.01-2022.12，卤代酚类有机污染物与甲状腺蛋白作用的分子机制研究，国家自然科学基金，21866011，主持，国家基金委
4. 2017-09-2020-09，多溴二苯醚及其衍生物与甲状腺转运蛋白结合作用研究，广西科技计划项目，2017GXNSFAA198354，主持，广西科技厅
5. 2015-01-2018-12，白腐真菌P450酶对双酚A类的降解及计算机分子模拟研究，国家自然科学基金，21467006，参与，国家基金委
6. 2014.01-2017.03，双酚A与P450酶相互作用的分子模拟与构效关系研究，广西科技计划项目，2014GXNSFAA118034，参与，广西科技厅
7. 2013.01-2015-12，有机磷系阻燃剂毒性的QSAR评价技术（863计划子项目，有机磷系阻燃剂的环境监测与毒性效应评价技术，2013AA065201），主持，国家科技部
8. 2013.04-2016-03，多溴二苯醚与人血清白蛋白的相互作用研究，广西自然科学基金，2013GXNSFAA019034，主持，广西科技厅
9. 2013.01-2015.12，全氟化合物与人血清白蛋白的相互作用研究，博士启动基金，主持，必赢bwin线路检测
10. 2013.01-2016.12, 典型环境PBDEs 与人血清白蛋白的相互作用及其构效关系研究，国家自然科学基金，21267008，主持，国家基金委
11. 2012-01-2015-04，多组分荧光免疫分析结合化学计量学方法用于生物体液中多项肿瘤标记物的无干扰同时定量检测，广西自然科学基金项目，2012GXNSFBA053029，参与，广西科技厅
12. 2012-01-2015-05，基于二阶校正的三维荧光分析用于药物与DNA的相互研究，广西高等学校科研项目，201203YB090，参与，广西教育厅
13. 2012.01-2013.12，PBDEs 与P450 相互作用的模拟研究，环境化学与生态毒理学国家重点实验室开放基金，KF2011-21，主持，环境化学与生态毒理学国家重点实验室
14. 2012.01-2015.12，典型环境PBDE 酶促代谢及其构效关系研究，国家自然科学基金，21167006，主持，国家基金委
15. 2011.03-2014.03, 典型环境PBDEs 酶促代谢机理的实验与模拟研究，广西自然科学基金，2011GXNSFA018061，主持，广西科技厅
申请专利：
1. 张爱茜，易忠胜，穆云松，蔺远，高常安，李富华. 污染物定量结构活性相关模型结构描述符筛选终止的方法，2011.08，申请号：CN 102156791 A
2. 张爱茜，易忠胜，李富华，蔺远，高常安，穆云松. 有机污染物定量结构活性相关模型抽多法交叉验证方法，2011.09，申请号：CN 102184284 A
3. 易忠胜，刘红艳，莫凌云. 有机污染物定量构效活性相关建模的变量筛选方法，2012.05，申请号：CN 102682209 A
4. 刘红艳，邢贺，马钰，张泽雄，易忠胜，一种利用白腐真菌粗酶液降解双酚E的方法，申请日：2017.04.18，公开号: CN107096160A
5. 陶慧林，廖秀芬，徐铭泽，谢襄漓，钟福新，易忠胜，一种检测人血清中痕量免疫球蛋白G浓度的方法，申请日：2014.05.11，公开号 : CN103969446A
6. 陶慧林，廖秀芬，徐铭泽，黎舒怀，钟福新，易忠胜，一种快速检测河水中痕量Hg2+浓度的方法，申请日 : 2014.05.11，公开号 : CN103969237A
7. 陶慧林，廖秀芬，孙超，谢襄漓，钟福新，易忠胜，黄艺鹏，利用荧光碳点与碲化镉量子点能量转移技术检测农田水中绿麦隆含量的方法，申请日 : 2014.04.16，公开号 : CN103901007A
8. 陶慧林，徐铭泽，易忠胜，张庆军，艾芳婷，陈杵序，利用开关型荧光能量转移体系检测多溴联苯醚残留的方法，申请日 : 2013.10.15，公开号 : CN103487417A
计算机软件著作权：
1. 环境内分泌干扰物活性预测和模式识别系统软件(EDCAPPR)，2011SR002274，2011.01.17，国家版权局
2. 通用变量筛选与建模程序(GVSMP)，2015SR123587，2015.07.03，国家版权局
3. LIBSVM_Assistant，2015SR206681，2015.10.27，国家版权局
4. Molcular Descriptor Calculator，2016SR025450，2016.02.02，国家版权局
